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Fentanyl makeover: Core structural redesign could lead to safer pain medications


Modified molecule shows diminished respiratory depression—the leading cause of opioid overdose deaths—while retaining full pain-blocking capability. February 11, 2026 LA JOLLA, CA—Fentanyl is one of the most effective drugs for managing severe pain, yet it carries substantial risks of addiction and respiratory depression, the dangerous and sometimes fatal slowed breathing.

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Fentanyl makeover

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structural redesign