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3D-printed living lung tissue
Printed tissue enables better testing of drugs and disease pathways
Dr. Emmanuel Osei, Assistant Professor in the Irving K. Barber Faculty of Science, says the model produces tissue that closely resembles the complexity of a human lung, enabling improved testing of respiratory diseases and drug development. The research team used a bioink composed of light-sensitive polymer-modified gelatin and a polymer called polyethylene glycol diacrylate to 3D print a hydrogel that includes multiple cell types and channels to recreate vessels, mimicking the structure of a human airway. The paper detailed tests, including exposing the bio-printed 3D model to cigarette smoke extract, allowing the researchers to observe increases in pro-inflammatory cytokines, or markers of inflammatory responses to nicotine in lung tissue.
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