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“Bottlebrush” particles deliver big chemotherapy payloads directly to cancer cells | Outfitted with antibodies that guide them to the tumor site, the new nanoparticles could reduce the side effects of treatment.
Using nanoparticles shaped like bottlebrushes, MIT chemists can deliver a large range of chemotherapy drugs directly to tumor cells, which could reduce the side effects of treatment.
After the particles reach a tumor site, some of these linkers are broken right away, allowing the drugs to kill nearby cancer cells even if they don’t express the target antibody. For this study, the researchers created ABC particles carrying a few different types of drugs: microtubule inhibitors called MMAE and paclitaxel, and two DNA-damaging agents, doxorubicin and SN-38. They also designed ABC particles carrying an experimental type of drug known as PROTAC (proteolysis-targeting chimera), which can selectively degrade disease-causing proteins inside cells.
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