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'Smart' antibiotic can kill deadly bacteria while sparing the microbiome
Compound called lolamicin targets a group of harmful microbes but does not disturb those that live peacefully in the gut.
Gram-negative bacteria such as Klebsiella pneumoniae(artificially coloured) are often resistant to multiple antibiotics, but they succumb to a new compound called lolamicin.Credit: Dr Tony Brain/Science Photo Library The bacteria have “multiple barriers that prevent antibiotic penetration”, says molecular biologist Zemer Gitai at Princeton University in New Jersey, who was not involved in the research. Gitai says that the study “proves the viability” of targeting the Lol system, but adds, “There is a long road from showing efficacy in mice to developing a drug for human use.”
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