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“Zombie” COVID particles may be responsible for lethal disease
Following the emergence of SARS-CoV-2 in 2020 there are now seven different coronaviruses known to infect humans. Four of those are associated with generally harmless common respiratory infections, but the other three (SARS, SARS-CoV-2 and MERS) are much more dangerous.
“It is interesting that the human peptide being imitated by the viral fragments has been implicated in rheumatoid arthritis, psoriasis and lupus, and that different aspects of COVID-19 are reminiscent of these autoimmune conditions.” Here the researchers indicate the striking uniqueness in each individual person’s enzyme efficiency could likely account for why some people don’t even notice they have COVID, while others end up struggling in hospital. “... proteolytic degradation of SARS-CoV-2 is likely to be heterogeneous, as individual hosts display distinctive patterns of enzyme efficiencies varying routinely by fourfold to 50-fold, with protein expression being 'noisy' even at the single cell level,” the researchers write in the new study.
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