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A dedicated skin-to-brain circuit for cool sensation in mice
A newly mapped neural circuit shows how our skin senses cool temperatures and sends that info to the brain, revealing an unexpected amplifier in the spinal cord and offering insight into cold-related pain.
This work deepens our understanding of fundamental biology and brings us closer to an explanation for how we evolved to inhabit safe temperatures and avoid dangerous extremes, Duan said. In their study, published in the journal Nature Communications, Duan and his team used sophisticated imaging techniques and electrophysiology to observe how mice transmitted the sensation of cool temperatures from their skin to the brain. Headed by postdoctoral research fellow Hankyu Lee and doctoral students Chia Chun Hor and Lorraine Horwitz, the team turned its focus to temperature in this work.
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