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A Major GLP-1 Drug Shortage Is Over. Some Patients Aren’t Celebrating


Mounjaro and Zepbound are now out of shortage. This should be good news—but because so many patients are taking compounded versions of these GLP-1 medications, it’s a complicated situation.

It has been a long time coming: The active ingredient in the weight loss drug Zepbound and diabetes medication Mounjaro has experienced runaway popularity, along with other GLP-1 meds like Ozempic. Most of the pharmacies compounding these meds are 503a—which means that the supply is already slowing, and in some cases lurching to an abrupt halt, for a large number of people who have come to rely on this medication. “It would make sense that people would panic over a shortage,” says Maria Rising, a compounded tirzepatide patient who also runs a popular Instagram channel about the medication.

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