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A newly discovered receptor switch that boosts bone growth could transform how we treat osteoporosis, by stimulating the body’s own bone-building machinery using a targeted drug and even mechanical force.
A newly discovered receptor switch that boosts bone growth could transform how we treat osteoporosis, by stimulating the body’s own bone-building machinery using a targeted drug and even mechanical force.
A new study led by the University of Leipzig in Germany has identified a critical regulator of bone formation, the G protein-coupled receptor 133 (GPR133), and a way to stimulate it – opening the door to a new strategy to treat or prevent osteoporosis. “If this receptor is impaired by genetic changes, mice show signs of loss of bone density at an early age – similar to osteoporosis in humans,” said the study’s senior author, Professor Ines Liebscher, MD, PhD, from the Leipzig University’s Rudolf Schönheimer Institute of Biochemistry. “The newly demonstrated parallel strengthening of bone once again highlights the great potential this receptor holds for medical applications in an aging population,” said lead author Dr Juliane Lehmann, also from Leipzig’s Biochemistry Institute.
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