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A primer on the next generation of antibodies

what's wrong with antibodies? what are some of the potential fixes? how do they work?

Because of higher stability, they show high refolding efficiency, which means raising or lowering the sample temperature does not affect Nb conformation, i.e., it de-binds and binds to the target, respectively, without any aggregation or denaturation [48]. The storage angle is great: most antibody mimetics are based on highly stable protein scaffolds, making them more resistant to harsh conditions such as extreme pH, temperature, and presence of proteases. The future very much looks like antibodies mimetics; custom-built antigen-binding protein able to be precisely tuned for their exact task, no attachment to shapes or binding sites, only focusing on efficacy, stability, and ease of production.

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