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Adipose tissue retains an epigenetic memory of obesity after weight loss
Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to the problematic ‘yo-yo’ effect often seen with dieting.
e, Top (significant) pathway terms for genes linked to newly emerged acetylated enhancers for H and HC (left) and HH and HHC (right) on the basis of WikiPathways database (Fisher’s exact test, adjusted P< 0.05 by the Benjamini–Hochberg method for correction). Indeed, BaS is a successful but invasive method for achieving long-term WL 53, yet sleeve gastrectomy and Roux-en-Y gastric bypass (RYGB) also affect the gut microbiome, micronutrient absorption, bile acid metabolism and incretin signalling 54, 55, 56, 57. Further investigations are required to determine whether—in addition to adipocytes and macrophages 28 —other post-mitotic or cycling cells, such as myofibers, neurons or APCs, also establish an epigenetic memory of obesity and contribute to the observed systemic weight regain effect.
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