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Alzheimer's biomarkers now visible up to a decade ahead of symptoms


Researchers at the University of Pittsburgh have devised a biomarker test that can spot small amounts of clumping tau protein in the brain and cerebrospinal fluid, which lead to Alzheimer's disease.

Researchers at the University of Pittsburgh have devised a biomarker test that can spot small amounts of clumping tau protein in the brain and cerebrospinal fluid, which lead to Alzheimer's disease. “Early detection is key to more successful therapies for Alzheimer’s disease since trials show that patients with little-to-no quantifiable insoluble tau tangles are more likely to benefit from new treatments than those with a significant degree of tau brain deposits," explained Thomas Karikari, senior author of the paper published in Nature this week. The two specific spots they found (called p-tau-262 and p-tau-356) work like early warning signals, letting doctors know that tau proteins are beginning to malfunction.

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