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Anti-aging medicine just gained 371 entirely new genetic targets | Scientists have mapped the most detailed genetic blueprint of frailty, offering new hope in the development of effective anti-aging therapies.
In a groundbreaking study, scientists have mapped the most detailed genetic blueprint yet of frailty – the age-related decline in resilience that affects around 40% of people aged 65 and above, dramatically increasing the risk of hospitalization, disability and death. The findings offer new hope in…
In a groundbreaking study, scientists have mapped the most detailed genetic blueprint yet of frailty – the age-related decline in resilience that affects around 40% of people aged 65 and above, dramatically increasing the risk of hospitalization, disability and death. Using a combination of genetic tools – genome-wide association studies (GWAS) and genomic structural equation modeling (gSEM) – the team scanned millions of DNA markers to find variants linked not just to one symptom at a time, but to the overlapping biology that underlies multiple frailty traits. "What this paper does is not only identify sub-facets of disordered aging but also demonstrate that there is very different biology underlying them," said senior author Andrew Grotzinger, assistant professor of psychology and neuroscience at CU Boulder.
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