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Autism's Four Core Subtypes
People belonging to the same subtype share genetic variants, behaviors and often co-occurring diagnoses, according to a new preprint.
People of the same subtype often harbor the same autism-linked common variants, according to a comparison of polygenic scores for 2,293 of the autistic children and 3,179 unaffected siblings from the SSC. For example, the variants detected among the mildly autistic group alter histone methylation, whereas those identified in the developmental delay subtype affect neuronal action potentials. The subtype characterized by developmental delay—which consisted of children diagnosed with autism at an early age—possesses variants that affect gene expression during fetal and neonatal development.
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