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Blood clotting discovery opens "whole new chapter in vascular biology"
Researchers have identified a previously unknown biological process that causes tissue and organ damage in conditions where oxygen is low, such as heart attacks and strokes. The study suggests that bursting red blood cells, not blood clots, are the culprits.
A new study by a team of researchers from institutes in Australia and New York has identified a previously unknown biological process that causes tissue and organ damage in low-oxygen conditions. “We’ve discovered a completely new blood-clotting mechanism that has nothing to do with the traditional clotting system involving platelets or fibrin,” said corresponding author Professor Shaun Jackson, founder and director of ThromBio, a drug discovery company focused on developing anti-clot medications. According to the traditional clotting pathway, when a blood vessel is injured, tiny cell fragments called platelets quickly stick to the damaged site and one another, forming a temporary plug.
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