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Brain circuit scores identify clinically distinct biotypes in depression/anxiety
Personalized brain circuit measures quantified using a new imaging technology in 801 patients with depression and anxiety identify six biotypes with unique symptoms, behaviors and responses to different types of treatment.
This is analogous to cardiac imaging being collected during both rest and task conditions in which the activity of the heart is elicited (for example, stress tests) to enable precise diagnoses and treatment plans, a necessity given the complexity of this organ and its functions 8. In the present study, we demonstrate a new approach to generating biotypes of depression and anxiety based on task-evoked and task-free imaging data, quantified at the individual patient level and evaluated in the context of transdiagnostic symptoms, behaviors and outcomes with multiple types of treatments. We began by implementing a new standardized image-processing procedure called ‘the Stanford Et Cere Image Processing System’ which quantified task-free and task-evoked brain circuit function at the level of the individual participants ( Methods).
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