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Brown fat “repressor” protein targets cancer-related weight loss | The discovery opens the door to developing treatments for the extreme weight loss, muscle wasting, and malnutrition seen in some types of cancer.
For the first time, researchers have identified a protein that represses the activity of energy-burning brown fat. The discovery opens the door to developing treatments for the extreme weight loss, muscle wasting, and malnutrition seen in some types of cancer.
Now, a new study led by researchers from the University of Barcelona (UB) in Spain has identified a protein molecule that represses the activation of BAT, and could be valuable for treating the malnutrition, weight loss and muscle wastage associated with some cancers. The researchers then created mice with the ACBP gene removed only in brown fat cells and exposed the animals to cold and high-fat diets to see how their BAT responded. The ACBP-less mice had higher BAT activity, produced more heat, had smaller fat stores, better blood sugar control, and gained less weight despite eating a high-fat diet.
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