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Building a Pause Button for Biology
Pressing pause on biological time, for those who need it most.
Pausing molecular motion in donor organs after excision would remove biologically-imposed time constraints upon testing and matching procedures, improving outcomes by reducing rejection rates amongst recipients. Fortunately, preparing the system in advance by perfusing molecular cryoprotective agents (CPAs) while the tissue, organ, or patient is held at hypothermic temperatures can dramatically reduce ice nucleation and extension rates during the cooling phase. Fortunately, preparing the system in advance by perfusing molecular cryoprotective agents (CPAs) while the tissue, organ, or patient is held at hypothermic temperatures can dramatically reduce ice nucleation and extension rates during the cooling phase.
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