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Caged drugs still 'STING' cancer, but make treatment much safer | The new drug-delivery system only activates when inside a tumor and calls upon the body's own immune system to destroy it
A new breakthrough from researchers at the University of Cambridge removes the dangers involved in a process called STING, in which the body's own immune system can be enlisted to fight cancer. The finding clears the way for a powerful, and safe, weapon against tumors.
A new breakthrough from researchers at the University of Cambridge removes the dangers involved in a process called STING, in which the body's own immune system can be enlisted to fight cancer. In this case, the caged drug, which is a STING agonist known as MSA2, is released when it encounters an enzyme called β-glucuronidase, which is produced by tumors and not typically found in healthy tissue. “This discovery is exciting not only for cancer treatment, but also as a new way of thinking about how we make medicines safer and more precise,” concluded study first author Nai-Shu Hsu.
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