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Cancer protein discovery reveals new treatment target
Researchers have discovered how a particular protein affects the growth and spread of colon cancer in humans. The study not only improves our understanding of why this type of cancer can be aggressive in some people, but it also highlights a potential treatment target.
The study not only improves our understanding of why this type of cancer can be aggressive in some people, but it also highlights a potential treatment target. “In CRC, higher levels of DUSP6 have been found in tumors, where it helps the cancer cells grow faster, spread more easily, and leads to poorer outcomes for patients,” said Associate Professor Zhang Yongliang from NUS Medicine’s Department of Microbiology and Immunology and the study’s corresponding author. Through dephosphorylation, DUSP6 helps control the duration and intensity of ERK signaling, which is crucial for avoiding excessive or prolonged activation that could result in uncontrolled cell growth or other harmful cellular behaviors.
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