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Chinese researchers develop cocktail hydrogel for brain injury therapy

A group of Chinese researchers has developed a cocktail hydrogel that promotes the regeneration of the neurovascular unit and repairs damaged brain tissue, offering a significant theoretical foundation and innovative strategies for cell replacement therapy for cortical brain injuries.

Researchers at the Guangzhou Institutes of Biomedicine and Health under the Chinese Academy of Sciences have developed a new cocktail hydrogel featuring a three-dimensional scaffold structure with biomimetic properties. According to a recent paper published in the Journal of Advanced Research, the material simulates the biochemical and mechanical environment of the natural extracellular matrix, significantly enhancing the adhesion, survival and lineage-specific differentiation of human NPCs. The study also found that the hydrogel helps reconstruct the microstructure of the neurovascular unit, significantly improves the local immune and metabolic microenvironment at injury sites, and promotes both the survival of human NPCs and their differentiation into cortical interneurons.

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