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Cysteine depletion triggers adipose tissue thermogenesis and weight loss
The authors describe how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans.
It remains unclear whether cysteine specifically controls organismal metabolism and whether sustained CR in healthy humans can help understand the fundamental relationship between energy balance and SAA homeostasis pathways that converge to improve healthspan and lifespan. r, Analysis of EPR spectra of POBN-lipid radical adducts measured in Folch extracts of visceral adipose depot (VFAT), SFAT and BAT tissues from Cth −/ − mice fed with CTRL or CysF diet for 5 days, normalized to 100 mg (ND, not detectable; n= 5–6 per group). The in vivo spin trapping and electron paramagnetic resonance (EPR) spectroscopy revealed that cysteine deficiency significantly increased lipid-derived radicals in BAT with undetectable signals in white adipose tissue (WAT) (Fig.
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