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Dad's Diet Before Conception Affects Kids' Health
A father's diet before conception can impact his children's health, particularly their susceptibility to metabolic diseases.
The study, using data from the LIFE Child cohort and mouse models, revealed that paternal diet influences sperm RNA, affecting gene expression in offspring. In humans, mt-tsRNAs in spermatozoa correlate with body mass index, and paternal overweight at conception doubles offspring obesity risk and compromises metabolic health. Our study supports the importance of paternal health at conception for offspring metabolism, shows that mt-tRNAs are diet-induced and sperm-borne and demonstrates, in a physiological setting, father-to-offspring transfer of sperm mitochondrial RNAs at fertilization.
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