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Decades of Research Misconduct Stalled an Alzheimer's Cure


Research supporting the amyloid hypothesis—the idea that Alzheimer's is caused by a buildup of amyloid plaques in the brain—was fraudulent.

For decades scientists had struggled fruitlessly to offer hope to millions of patients who suffer the gradual, debilitating decline in their ability to think and remember loved ones, or enjoy self-aware lives. In the United States alone, more than eleven million family members care for fathers and mothers and grandparents who have fallen prey to the cruel disease that begins by gradually stealing a person’s mastery of everyday life, then cherished memories, and finally the sense of self that makes each of us human. If Leqembi and look-alikes with similarly lackluster results hold sway in drug development and dominate mindshare among patients and doctors, a genuine Alzheimer’s cure might become even more remote.

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