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Deletion of Il11 extended the lives of mice by 25%
IL-11 is identified as a key regulator of ERK–AMPK–mTORC1 signalling, metabolism, inflammation and age-related disease and lifespan in mouse and human.
We highlight that although we excluded food intake and enteric or locomotor-related energy expenditure and showed WAT beiging across genetic and therapeutic models, we did not pinpoint the specific physiology leading to weight loss with IL-11 inhibition. Lipid droplet areas were quantified by ImageJ (version 1.53t, NIH) with the adipocytes tools plugin ( https://github.com/MontpellierRessourcesImagerie/imagej_macros_and_scripts/wiki/Adipocytes-Tools) from 5 randomly selected fields at 200× magnification in vWAT images per mouse, and 5 mice per group were assessed. a. Violin plot of Transcripts per million (TPM) values of senescence genes (based on Tabula Muris Senis consortium) in vWAT, liver, gastrocnemius samples from mice receiving either IgG or anti-IL11 as shown in schematic Fig.
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