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Developing Kidneys from Scratch: Alex Hughes Tackles the Tremendous Burden of Kidney Disease
Penn's Alex Hughes is unraveling the mysteries of kidney development in order to develop artificial kidney tissue that could save lives.
Most people only ever see the organ in cross-section, through textbooks or by dissecting animal kidneys in high school biology class: a bean-shaped slice with lots of tiny tubes. Ultimately, Hughes hopes to combine these dual insights — into the mechanical stress waves that influence kidney development, and the ratios that shape organoid formation — into clinical applications. Additional co-authors of the papers referred to include Aria Zheyuan Huang, Trevor J. Chan, Gabriela Hayward-Lara and Catherine M. Porter of Penn Engineering, and Chenjun Shi and Jitao Zhang of Wayne State University.
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