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Dietary restriction impacts health and lifespan of genetically diverse mice
Health effects of dietary restriction are uncoupled from longevity.
Mice were initially exposed to white noise from an overhead speaker, which transitions to a series of randomized, computer-generated stimuli ranging in volume from 70 to 120 decibels at 40 ms in duration and an interval of 9–22 s. The test runs for approximately 30 min. Lifespan Research staff regularly evaluated mice for prespecified clinical symptomology: palpable hypothermia, responsiveness to stimuli, ability to eat or drink, dermatitis, tumours, abdominal distention, mobility, eye conditions (such as corneal ulcers), malocclusion, trauma and wounds of aggression. If the clinical team determined a mouse to be palpably hypothermic and unresponsive, unable to eat or drink, and/or met protocol criteria for severe dermatitis, tumours and/or fight wounds, pre-emptive euthanasia was performed to prevent suffering; otherwise, the veterinary staff provided treatment.
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