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Directly converting skin cells to brain cells yields 1,000% success | Scientists have managed to convert mouse skin cells directly into motor neurons, skipping the usual step of stem cells in between
In a potentially major breakthrough for regenerative medicine, scientists at MIT have developed a way to convert skin cells directly into brain cells extremely efficiently, without needing to go through the intermediate step of converting them to stem cells first.
Cooking up a batch of stem cells to treat illness or injury used to involve the ethically hairy practice of harvesting them from embryonic tissue. “Oftentimes, one of the challenges in reprogramming is that cells can get stuck in intermediate states,” said Katie Galloway, senior author of two papers describing the new technique. Mouse motor neurons (green) grown directly from skin cells were able to integrate with others in the animal's brain after transplantation
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