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Discovery of death-defying molecule could slow Parkinson’s progression | A molecule that blocks cell death could mean treatments for Parkinson's and other degenerative diseases
In a new study, researchers have identified a way to stop cells from dying, opening the door to developing treatments that slow the progression of neurodegenerative conditions like Parkinson’s disease.
Now, led by the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne, Australia, a new study has discovered how to do the opposite: block cell death by targeting one of these proteins, opening the door to treatments that stop the progression of neurodegenerative conditions like Parkinson’s disease. With this in mind, the researchers relied on the ultra-high throughput screening capabilities of the WEHI-based National Drug Discovery Center, to sift through 106,572 compounds to identify one that targeted one cell-killing protein, BAX. “We were thrilled to find a small molecule that targets a killer protein called BAX and stops it working,” said co-corresponding author and the Head of WEHI’s New Medicine and Diagnostics division, Professor Guillaume Lessene.
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