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Dual-action antibiotic could make bacterial resistance nearly impossible


A new antibiotic that works by disrupting two different cellular targets would make it 100 million times more difficult for bacteria to evolve resistance, according to new research from the University of Illinois Chicago. For a new paper in Nature Chemical Biology, researchers examined how a class of synthetic drugs called macrolones disrupt bacterial cell function to fight infectious diseases.

A new antibiotic that works by disrupting two different cellular targets would make it 100 million times more difficult for bacteria to evolve resistance, according to new research from the University of Illinois Chicago. Listen to story summaryFor a new paper in Nature Chemical Biology, researchers examined how a class of synthetic drugs called macrolones disrupt bacterial cell function to fight infectious diseases. In addition to Mankin, Polikanov and Vázquez-Laslop, UIC co-authors on the paper include Elena Aleksandrova, Dorota Klepacki and Faezeh Alizadeh.

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Dual action antibiotic could make bacterial resistance nearly impossible