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Effect of chewing hard material on enhancing cognitive function
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Participants were positioned supine with their heads stabilized using a fixation device and instructed to chew either paraffin wax gum (CAT 21 Buf Test, Morita Co., Japan) or a wood stick (Tongue Depressors, Daehan medical, Korea) for 5 min. The basis set for spectral fitting of GSH-edited difference spectra included GSH, NAA, N-acetylaspartateglutamate (NAAG), aspartate, lactate, myo-inositol (MI), phosphocholine (PCh), glycerophosphocholine (GPC), threonine, phosphoethanolamine, and glucose. An MRS study using MEGA-PRESS sequence provided in vivo evidence that the patients with Alzheimer’s disease exhibit reduced GSH concentrations in the frontal cortex compared to age-matched healthy controls ( Mandal et al., 2015).
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