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Enzyme behind diet-induced obesity and diabetes can be ‘switched off’ | Switching off an enzyme in mice prevented diet-induced obesity and improved metabolism
Switching off a single enzyme in immune cells protected mice from obesity, type 2 diabetes, and fatty liver disease in a new study, offering a potential new treatment target for metabolic disorders.
Switching off a single enzyme in immune cells protected mice from obesity, type 2 diabetes, and fatty liver disease in a new study, offering a potential new treatment target for metabolic disorders. Now, a new study by researchers at Monash University, Melbourne, and Baylor College of Medicine, Texas, has identified an enzyme, CAMKK2, that, when “switched off” in immune cells, prevented diet-induced obesity, diabetes and fatty liver disease in mice. Without CAMKK2, macrophages had an anti-inflammatory profile, produced few inflammatory signals, and showed a preference for burning fat as fuel through increased fatty acid oxidation and improved mitochondrial function.
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