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ESM3: Simulating 500M years of evolution with a language model
cale More than 3.5 billion years ago, life on Earth emerged from chemical reactions. Nature invented RNA, proteins, and DNA, the core molecules of life, and created the ribosome, a molecular factory that builds proteins from instructions in the genome.
For example, the model can be prompted to combine structure, sequence, and function to propose a potential scaffold for the active site of PETase, an enzyme that degrades polyethylene terephthalate (PET), a target of interest to protein engineers for breaking down plastic waste. This protein, located in well B8 of our experiment plate, was 50x less bright than natural GFPs and its chromophore matured over the course of a week, instead of in under a day, but it presented a signal of function in an unexplored portion of sequence space. If you are working on these kinds of problems we would love to hear about how you think ESM3 can help and will be prioritizing beta access to the API based on potential to expand the frontiers of scientific knowledge and create new tools that can benefit the world.
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