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Evidence for ~12-h ultradian gene programs in humans
Mice and many marine organisms exhibit ~12-h ultradian rhythms, however, direct evidence of ~12-h ultradian rhythms in humans is lacking. Here, we performed prospective, temporal transcriptome profiling of peripheral white blood cells from three healthy humans. All three participants independently exhibited robust ~12-h transcriptional rhythms in molecular programs involved in RNA and protein metabolism, with strong homology to circatidal gene programs previously identified in Cnidarian marine species.
K~ 12-h rhythms of intron retention events (top) and RNA splicing genes expression (bottom) are attenuated by liver-specific loss of function of XBP1 ( Xbp1 LKO: red), relative to control ( Xbp1 Flox: black) in mice. On the morning of admission, participants selected items from a food menu designed to match their standard daily caloric intake with a uniform macronutrient composition of 55% carbohydrates, 25% fat, 20% protein per day. Bokai Zhu, Natalie L. David, William Dion, Nandini K. Doshi, Tânia Amorim, Rosemary E. Andrews, G. V. Naveen Kumar, Saad Irfan, Tristan Pesaresi, Ankit X. Sharma, Michelle Sun & Matthew L. Steinhauser
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