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Fecal transplants reduce alcohol cravings as human trials progress
Researchers at Virginia Commonwealth University have found fecal transplants may be helpful in reducing drinking behaviors in those suffering severe alcohol use disorder (AUD). The work points to a compelling relationship between the gut microbiome and addiction disorders, with large-scale Phase 2…
The cohort randomly received either a placebo or active FMT gathered from a single donor high in Lachnospiraceae and Ruminococcaceae, two types of gut bacteria seen in low levels in AUD patients. “We conclude in this Phase 1 trial that FMT in men with cirrhosis is safe, associated with reduction in short-term craving and consumption with beneficial microbial change,” the researchers wrote in the conclusion to the study reporting preliminary data in 2020. A study from Bajaj and colleagues published in 2022 found stool samples collected from Phase 1 trial participants at the end of the experiment were successful in reducing alcohol-seeking behaviors when transplanted into mice.
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