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First proof brain’s powerhouses drive – and can reverse – dementia symptoms


Just a few days after scientists announced we're at a pivotal tipping point in Alzheimer's disease research, a team has made a huge breakthrough, proving for the first time how mitochondrial dysfunction fuels neurodegenerative symptoms. Through this, they created a precision tool that restored…

Just a few days after scientists announced we're at a pivotal tipping point in Alzheimer's disease research, a team has made a huge breakthrough, proving for the first time how mitochondrial dysfunction fuels neurodegenerative symptoms. Researchers from France's Inserm and the University of Bordeaux, along with a team at Canada's Université de Moncton, have for the first time identified a causal link between mitochondrial dysfunction and the debilitating symptoms that emerge and worsen in neurodegenerative diseases. The discovery finally pushes the science beyond association, showing causal proof that mitochondrial impairment actively drives cognitive symptoms, and that restoring energy production can quickly reverse them – and it still worked even amid other changes in the brain typical of neurodegenerative disease progression.

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