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Francis Crick's "Central Dogma" was misunderstood
The Central Dogma is not a 'dogma,' and it has never been broken.
Many students are taught that the Central Dogma is simply “DNA → RNA → protein.” This version was first put forward in Jim Watson’s pioneering 1965 textbook, The Molecular Biology of the Gene, as a way of summarizing how protein synthesis takes place. In other cases, researchers have pointed to epigenetics as a possible exception to Crick’s Central Dogma, arguing that changes in gene expression are transmitted across the generations and thus provide an additional, non-nucleic source of information. In 2003, near the end of his life, Crick heard that Phil Sharp (1993 Nobel Prize in Physiology or Medicine) was planning to mark the 50 th anniversary of the double helix’s discovery by giving a talk on exceptions to the Central Dogma.
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