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Genetic cloaking of healthy cells opens door to universal blood cancer therapy
Blood stem cells are being engineered to protect them from lethal therapies.
For the strategy, researchers collect healthy blood stem cells and genetically engineer tiny, benign changes to a common molecular marker on them. Those trials using the strategy "are eagerly anticipated by the scientific and medical community," oncologist Miriam Kim of the Washington University School of Medicine wrote in Trends in Cancer in December. The antibody part of the ADC is a protein that can uniquely latch onto CD45 and, once attached, deliver a toxic payload bound to it, which contains an existing cell-killing drug.
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