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Genetic code enables zebrafish to mend damaged organs
New research identifies the genes necessary for zebrafish to regenerate their hearts after damage—work that could ultimately impact the recovery of human patients after heart attacks.
The research was a collaboration between the laboratories of Marianne Bronner, Caltech's Edward B. Lewis Professor of Biology and director of the Beckman Institute, and developmental biologist Megan Martik of UC Berkeley. The Bronner and Martik laboratories have studied neural crest cells and their crucial role in development in many lab animal models, including zebrafish and lamprey. These genes, the researchers found, are crucial for normal embryonic development and then are inactivated during the animal's adult life—but are reactivated to enable tissue regeneration.
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