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German man who got 134 to 217 Covid shots over 29 months had no negative effects to immune system
It conflicts with concerns of repeat boosters, but authors warn against hypervaccination.
In cases of chronic exposure to a disease-causing germ, "there is an indication that certain types of immune cells, known as T-cells, then become fatigued, leading to them releasing fewer pro-inflammatory messenger substances," according to co-lead study author Kilian Schober from the Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene. The German man's extreme history of hypervaccination seemed like a good case to look for evidence of such tolerance and weaker responses. "In summary, our case report shows that SARS-CoV-2 hypervaccination did not lead to adverse events and increased the quantity of spike-specific antibodies and T cells without having a strong positive or negative effect on the intrinsic quality of adaptive immune responses," the authors concluded.
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