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Harvard team built a CMOS chip to map 70,000 synaptic connections between 2,000 rat neurons


Research aims to understand large-scale neural networks via a leap in neuronal recording.

Harvard researchers built a complementary metal-oxide semiconductor (CMOS) chip packed with 4,096 microhole electrode arrays, allowing them to record electrical activity across several neural cells. (Image credit: Harvard John A. Paulson School of Engineering and Applied Sciences)This is a massive advancement in neuronal research, where scientists can accurately map every detail of neural connections within the brain. “One of the biggest challenges, after we succeeded in the massively parallel intracellular recording, was how to analyze the overwhelming amount of data,” said researcher Donhee Ham.

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