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Hay fever breakthrough: 'Molecular shield' blocks allergy trigger at the site | Scientists have developed a new antibody treatment that blocks pollen at the point of entry
Scientists have developed a nasal "molecular shield" that disarms pollen, blocking allergic reactions fast without the use of drugs. This non-invasive method to effectively silence hay fever could be a game changer for the roughly 81 million Americans currently in a lifelong battle with airborne…
“This is the first time a monoclonal antibody designed to block a specific pollen allergen has been delivered directly into the nose, and been shown to protect against allergy symptoms in the upper and lower airways,” said senior author Kaissar Tabynov, a professor, and the director of the International Center for Vaccinology at KazNARU. "This ‘molecular shield' not only prevents IgE antibodies from being activated, but may also reduce inflammation through other mechanisms, such as calming immune cell responses and promoting regulatory pathways." When XA19 antibodies were inserted into the nose of mice with pollen sensitivity, further testing showed a massive reduction in inflammation biomarkers and behaviors typically seen in rodents with allergic reactions to the irritant.
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