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High-resolution imaging method details nerves across a mouse’s body
High-resolution imaging method could lead to wiring diagram for the whole body.
The method, described today in Cell, is an important technical achievement, says Ann-Shyn Chiang, a neuroscientist at the National Tsing Hua University in Hsinchu, Taiwan, who was not involved with the research. To prepare a mouse’s body for the scan, researchers treat it with chemicals that make its tissues transparent by removing fat, calcium and other components that block light. “A slower system would take months or years, increasing the chance of mechanical failure, signal loss or sample degradation,” says co-author Guoqiang Bi, a neuroscientist at the University of Science and Technology of China in Hefei.
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