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How blockbuster obesity drugs create a full feeling — even before one bite of food
Scientists identify brain area that holds two groups of neurons: one for pre-meal sensations of fullness and one for post-meal satiety.
The identification of these two populations of neurons is the paper’s key contribution, says Allison Shapiro, a specialist in neurodevelopment at the University of Colorado Anschutz Medical Campus in Aurora, who was not involved in the research. The latest obesity medications mimic a hormone called glucagon-like peptide 1 (GLP-1), which controls blood-sugar levels and acts on the brain to curb appetite. Study co-author Hyung Jin Choi, a neuroscientist at Seoul National University, experienced the effects of liraglutide firsthand when he took the drug for obesity.
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