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How One Keto Trial Set Off a New War in the Nutrition World
A study claimed that people who eat high-fat, low-carb diets weren’t seeing their arteries fill up with plaque, despite having high levels of blood cholesterol. Critics disagreed—and all hell broke loose.
“I’m an editor at the American Journal of Clinical Nutrition,” Klatt says, “and I would like to believe that we would have rejected this outright without even sending it out for peer review, because it has so many obvious issues.” He is worried about people using this flawed study as proof the consensus on the risks of LDL cholesterol has been “debunked,” which it has not. One of the study’s coauthors, Matthew Budoff, a professor of medicine at UCLA as well as an investigator at the Lundquist Institute, acknowledged in an email to WIRED that there had been “incredible scrutiny of the data on social media, which is more than expected based on my prior publications.” He noted the research team is seeking to have the paper incorporate corrections, but that this is ultimately at the discretion of the journal. The reply goes on to state that the study’s findings were “compatible with a causal role of ApoB in atherosclerosis”—the build-up of fat in the arteries—which they’ve “acknowledged and supported in previous publications.” The letter says that not mentioning this percentage increase in NCPV “was a sincere oversight, not intentional selective reporting.”
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