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How to Scale Proteomics
A look inside Parallel Squared Technology Institute, a focused research organization trying to make analyzing a proteome as easy as DNA sequencing.
Instead of a clutter of experimental tools, like you might find in a standard molecular biology lab, the space is sparsely filled with machines to isolate cells, a handful of mass spectrometers, and computers to process data. If you combine the barcodes with timePlex, PTI has effectively already boosted the number of proteomes scientists can study in a single day by an order of magnitude, relative to prior state-of-the-art methods. Those datasets are useful but just a draft; they miss most protein-level events, including those that turn healthy Tau — a protein that stabilizes the internal structure of neurons — into the hyper-phosphorylated tangles that define late-stage Alzheimer’s.
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