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Imaging tech promises deepest looks yet into living brain tissue at single-cell resolution
A team of MIT Picower Institute scientists and engineers demonstrates a new microscope system capable of peering exceptionally deep into brain tissues to detect the molecular activity of individual cells by using sound.
“The major advance here is to enable us to image deeper at single-cell resolution,” says neuroscientist Mriganka Sur, a corresponding author along with mechanical engineering professor Peter So and principal research scientist Brian Anthony. In fact, says co-lead author and mechanical engineering postdoc W. David Lee, who conceived the microscope’s innovative design, the system could have peered far deeper, but the test samples weren’t big enough to demonstrate that. The new system achieved the depth and sharpness by combining several advanced technologies to precisely and efficiently excite the molecule and then to detect the resulting energy, all without having to add any external labels, either via added chemicals or genetically engineered fluorescence.
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