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Immunotherapy Is Changing Cancer Treatment Forever

Immunotherapy is making tumors melt away.

Patients will now have a short run of chemotherapy before the infusion to limit the number of CAR-T cells killed or inactivated by the innate immune system, allowing more of them to remain active at the tumor site for longer. When a Bethlehem Steel warehouse near Buffalo caught fire a few years ago, sending up a plume of smoke so large 300 households and several schools had to be evacuated, Tom determined that the culprit was an improperly installed lighting system that had thrown sparks onto flammable materials below. For all the time and money and innovation that went into producing that moment, the scene was oddly humble: a normal hospital room, Tom sitting up in his bed as a doctor wearing gloves pushed the plunger on a syringe.

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