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Inflammation jolts “sleeping” cancer cells awake, enabling them to multiply again
Chemotherapy-induced injury of organ tissue causes inflammation that awakens dormant breast cancer cells, leading them to multiply and potentially form new metastases, according to new research by MIT biologist Robert Weinberg and colleagues at the Whitehead Institute.
To investigate what makes this dormancy reversible months or years down the line, researchers in the Weinberg Lab injected human breast cancer cells into mice. Previous work from the Weinberg Lab had shown that inflammation in organ tissue can provoke dormant breast cancer cells to start growing again. The team has already identified one key player in the awakening process, but understanding the full set of signals and how each contributes is far more complex — a question they are continuing to investigate in their new work.
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