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Insilico Medicine unveils first AI-generated and AI-discovered drug in new paper
Startup Insilico Medicine announced it has created the first drug discovered and generated by AI, which is now in Phase II clinical trials.
The paper, in Nature Biotechnology, presents the entire journey of INS018_055, a drug candidate that was discovered using Insilico’s AI platform to treat idiopathic pulmonary fibrosis, a relatively rare but aggressive lung disease. The paper discloses the raw experimental data and the preclinical and clinical evaluation of the potentially first-in-class TNIK inhibitor discovered and designed through generative AI. Zhavoronkov said that while he typically does not celebrate, this groundbreaking achievement in AI-driven drug discovery — the culmination of a decade of work, since Insilico’s founding in 2014 — is an exception: “I’ll go and watch Dune,” he said, “with a big bag of popcorn.”
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