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Japan scientists mass-generate cells for sperm, eggs using human iPS


A research team at Kyoto University in western Japan has succeeded in mass-generating cells capable of turning into sperm or eggs by using human induced pluripotent cells, with the achievement expected to boost studies in reproductive medicine.

The research, published in the online edition of the British science journal Nature on Monday, amplified the number of male and female primitive germ cells over 10 billion times from their initial culture stage. The scientists hope their findings will eventually lead to the production of eggs and sperm that are generated from "primordial germ cells" through "pro-spermatogonia" and "oogonia." This time, the team succeeded in developing oogonia and pro-spermatogonia in two months by using primordial germ cell-like cells and adding bone morphogenetic protein signaling.

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